Structure-activity relations of teratogenic natural products

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Structure-activity relations of teratogenic natural products

Mammalian ingestion of jervane, solanidane, and spirosolane steroidal alkaloids produces craniofacial congenital malformations in offspring upon administration during the primitive s t rdneura l plate developmental phase. Structure-terata studies have shown that hamster teratogenicity induced by steroidal alkaloids is primarily related to the presence of C-5, C-6 unsaturation and secondarily to...

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ژورنال

عنوان ژورنال: Pure and Applied Chemistry

سال: 1994

ISSN: 1365-3075,0033-4545

DOI: 10.1351/pac199466102407